Improved Anisotropic Transport Through Polymer Layer and Porous Arterial Wall with Binding in Drug-Eluting Stents

Abstract

Dissolution in the polymer coating and specific binding in the artery wall play an important role in anisotropic transport of the antiproliferative/anti-inflammatory drugs. In this work, we consider the model of dissolution, transport and binding of sirolimus on an axisymmetric domain representing the polymer coating layer and the porous artery wall in the vicinity of a stent strut. The Finite Element Method (FEM) is used to discretize the porous media equations by an interconnected unstructured triangular mesh and an improved anistropic model is employed to accurately capture the correct effect of the diffusion tension seem in the sirolimus concentration distribution. Finally, we present the new results obtained to the characterization of the dynamics of the porous arterial wall with binding in drug-eluting stents.